Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche, Michael Acker, Andreea Argintaru, +61

Journal of Medicinal Chemistry

Dual Allosteric Inhibition of SHP2 Phosphatase

Michelle Fodor, Edmund V. Price, Ping Wang, +23

ACS Chemical Biology

Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor

Young Shin Cho, Julian Levell, Gang Liu, +24

ACS Medicinal Chemistry Letters

6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors

Patrick Sarver, Michael Acker, Jeffrey T. Bagdanoff, +27

Journal of Medicinal Chemistry

Medicinal ChemistryAllosteric Shp2 InhibitorsDrug TargetEfficacious Shp2 InhibitorsBiochemistry +13

Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors

Jeffrey T. Bagdanoff, Zhouliang Chen, Michael Acker, +23

Journal of Medicinal Chemistry

Medicinal ChemistrySignaling PathwayReceptor Tyrosine KinaseCell SignalingProtein Function +14

Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase

Andreas Lingel, Martin Sendzik, Ying Huang, +24

Journal of Medicinal Chemistry

Histone ModificationsEed Binders AllostericallyEpigenetic ChangeMolecular BiologyEpigenetics +19

Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies

Ying Huang, Martin Sendzik, Jeff Zhang, +38

Journal of Medicinal Chemistry

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors

B.A. Katz, Kyle Elrod, Erik Verner, +12

Journal of Molecular Biology

Protein ChemistryProtein AssemblyBiochemistryProtein FoldingNatural Sciences +6

A New Synthetic Approach to the C Ring of Known as Well as Novel Bryostatin Analogues

Paul A. Wender, Michael F. T. Koehler, Martin Sendzik

Organic Letters

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

Richard L. Mackman, Hon C. Hui, J. Guy Breitenbucher, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +7