Dean R. Artis

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations

Skin Cancer, Medicine, Melanoma +7

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang et al. · Proceedings of the National Academy of Sciences · 2008 · 1.3K citations · Full text

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

G.L. Card, B.P. England, Yoshihisa Suzuki et al. · Structure · 2004 · 425 citations · Full text

Drug Target, Biochemistry, Medicine +6

N-(Triisopropylsilyl)pyrrole. A progenitor "par excellence" of 3-substituted pyrroles

Brian L. Bray, Peter Mathies, Reto Naef et al. · The Journal of Organic Chemistry · 1990 · 233 citations

Chemical Analysis, Physicochemical Analysis, Par Excellence +7

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

G.L. Card, Landy K. Blasdel, B.P. England et al. · Nature Biotechnology · 2005 · 205 citations · Full text

Medicinal Chemistry, Biochemistry, Drug Design +9