Concepedia

Design, synthesis, and biological evaluation of novel 4,4′-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer

Gui‐Ping Gao, Jiayi Li, Yin Cao, Xudan Li, Yuqing Qian, Xiumei Wang, Meijuan Fang

European Journal of Medicinal Chemistry · 2023 · 17 citations · 28 references

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28

Hallmarks of Cancer: New Dimensions

Cancer Discovery · 2022 · 9.1K citations · Full text

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The cellular thermal shift assay for evaluating drug target interactions in cells

Rozbeh Jafari, Helena Almqvist, Hanna Axelsson et al. · Nature Protocols · 2014 · 1.5K citations

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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Baishan Jiang, Michael A. Erb, Yanke Liang et al. · Nature Chemical Biology · 2017 · 550 citations · Full text

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Triple-negative breast cancer has worse overall survival and cause-specific survival than non-triple-negative breast cancer

Xiaoxian Li, Jing Yang, Limin Peng et al. · Breast Cancer Research and Treatment · 2016 · 543 citations

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The structure of P‐TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

Sonja Baumli, Graziano Lolli, E.D. Lowe et al. · The EMBO Journal · 2008 · 353 citations · Full text

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