The structure of P‐TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

Sonja Baumli, Graziano Lolli, E.D. Lowe, +6

The EMBO Journal

Functional Architecture of RNA Polymerase I

Claus‐D. Kuhn, S. Geiger, Sonja Baumli, +7

Cell

EngineeringFunctional ArchitectureNatural SciencesRna Structure PredictionRna Biology +6

Structure and VP16 binding of the Mediator Med25 activator interaction domain

Erika Vojnic, André Mourão, Martin Seizl, +8

Nature Structural & Molecular Biology

Signal TransductionMedicineVp16 BindingMolecular BiologyBiochemical Interaction +4

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

Hao Shao, Shenhua Shi, Shi‐Liang Huang, +11

Journal of Medicinal Chemistry

Structure–activity RelationshipDrug TargetHeterocycle ChemistryChemical BiologyPharmaceutical Chemistry +15

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB

Sonja Baumli, Jane Endicott, L.N. Johnson

Chemistry & Biology

Molecular PharmacologyMedicinal ChemistrySelective P-tefb InhibitionDrug TargetBiochemistry +10

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

Karima Bettayeb, Claire Delehouzé, Nadège Loaëc, +8

Genes & Cancer

A Conserved Mediator Hinge Revealed in the Structure of the MED7·MED21 (Med7·Srb7) Heterodimer

Sonja Baumli, Sabine Hoeppner, Patrick Cramer

Journal of Biological Chemistry

Crystal StructureProtein X-ray CrystallographyMolecular BiologyStructure ElucidationStructural Biology +2

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

Alison J. Hole, Sonja Baumli, Hao Shao, +7

Journal of Medicinal Chemistry

Functional StudiesDrug TargetMolecular BiologyPharmacotherapyChemical Biology +22

Structure of the Mediator Subunit Cyclin C and its Implications for CDK8 Function

Sabine Hoeppner, Sonja Baumli, Patrick Cramer

Journal of Molecular Biology

Protein FunctionSignal TransductionBiochemistryNatural SciencesMolecular Biology +8

The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

Sonja Baumli, Alison J. Hole, M.E.M. Noble, +1

ACS Chemical Biology

Protein AssemblyViral Polymerase StructureStructural BioinformaticsMolecular BiologyHuman Immunodeficiency Virus +15