The dTAG system for immediate and target-specific protein degradation

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Nature Chemical Biology

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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Baishan Jiang, Michael A. Erb, Yanke Liang, +13

Nature Chemical Biology

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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

Georg Winter, Andreas Mayer, Dennis L. Buckley, +19

Molecular Cell

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Transcription control by the ENL YEATS domain in acute leukaemia

Michael A. Erb, Thomas G. Scott, Bin E. Li, +17

Nature

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ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

Liling Wan, Hong Wen, Yuanyuan Li, +15

Nature

Histone ModificationsChromatinHematological MalignancyChromatin RemodelingMixed-phenotype Acute Leukemia +9

Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma

Rhamy Zeid, Matthew A. Lawlor, Evon Poon, +16

Nature Genetics

Cell RegulationMycn-dependent Transcriptional AmplificationMedicineCell BiologyTumor Biology

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

Lara Gechijian, Dennis L. Buckley, Matthew A. Lawlor, +14

Nature Chemical Biology

Vhl LigandsMedicinal ChemistryBiochemistryNatural SciencesMolecular Biology +2

NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels

Roman H. Haefeli, Michael A. Erb, Anja C. Gemperli, +5

PLoS ONE

Lipid PeroxidationMolecular BiologyChemical BiologyRedox BiologyNqo1-dependent Redox Cycling +19

Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders

Mette Ishoey, Someth Chorn, Natesh Singh, +11

ACS Chemical Biology

Idebenone Protects against Retinal Damage and Loss of Vision in a Mouse Model of Leber’s Hereditary Optic Neuropathy

Fabrice D. Heitz, Michael A. Erb, Corinne Anklin, +3

PLoS ONE

Ocular DiseaseRetinal DamageOptogeneticsOxidative StressRetina +17