Bioprocess Challenges in Purification of Therapeutic Protein Charge Variants

Charge variants in IgG1

Leslie A. Khawli, Sirj Goswami, Ryan Hutchinson et al. · mAbs · 2010 · 406 citations · Full text

Immunocytochemical Technique, Immunology, Antibody Charge Variants +18

In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS

Lihua Huang, Jirong Lu, Victor J. Wroblewski et al. · Analytical Chemistry · 2005 · 263 citations

Immunology, Glycobiology, Immunotherapy +18

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

Josef Vlasak, Marie Claire Bussat, Shi‐Yi Wang et al. · Analytical Biochemistry · 2009 · 242 citations

Immunocytochemical Technique, Allergy, Autoimmune Disease +12

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain

Boxu Yan, Sean Steen, David M. Hambly et al. · Journal of Pharmaceutical Sciences · 2009 · 168 citations

Succinimide Formation, Asn 55, Immunocytochemical Technique +12

C‐terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes

Lawrence W. Dick, Difei Qiu, David Mahon et al. · Biotechnology and Bioengineering · 2008 · 156 citations

Immunocytochemical Technique, Immunology, Pathology +19