Concepedia

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain

Boxu Yan, Sean Steen, David M. Hambly, John Valliere‐Douglass, Tim Vanden Bos, Scott Smallwood, Zac Yates, Thomas Arroll, Yi-Hong Han, Himanshu S. Gadgil,

Journal of Pharmaceutical Sciences · 2009 · 170 citations · 34 references

DOI

Concepts

References

34

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

Terrence L. Geiger, Steven Clarke · Journal of Biological Chemistry · 1987 · 1.3K citations · Full text

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Challenges in the development of high protein concentration formulations

Zahra Shahrokh, Jun 军 Liu 刘 · Journal of Pharmaceutical Sciences · 2004 · 879 citations

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Molecular clocks

Noah E. Robinson, Arthur B. Robinson · Proceedings of the National Academy of Sciences · 2001 · 538 citations · Full text

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Succinimide Formation from Aspartyl and Asparaginyl Peptides as a Model for the Spontaneous Degradation of Proteins

Robert C. Stephenson, Steven Clarke · Journal of Biological Chemistry · 1989 · 518 citations · Full text

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Identification of multiple sources of charge heterogeneity in a recombinant antibody

Reed J. Harris, Bruce Kabakoff, Frank Macchi et al. · Journal of Chromatography B Biomedical Sciences and Applications · 2001 · 503 citations

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