Concepedia

Complementarity-determining Region Analysis

Complementarity-Determining Region Analysis is a methodological framework within antibody characterization that identifies and evaluates the hypervariable amino acid sequences in the antigen-binding sites of immunoglobulins to determine their role in molecular specificity and binding affinity.

444

Publications

29.4K

Citations

2.5K

Authors

659

Institutions

Publications per year

2017–2026

78

Parents

Publications

444

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

Leonard G. Presta, H Chen, Shane J. O'Connor et al. · PubMed · 1997 · 1.6K citations

, , +17

Replacing the complementarity-determining regions in a human antibody with those from a mouse

Peter Jones, Paul H. Dear, Jefferson Foote et al. · Nature · 1986 · 1.4K citations

, , +13

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

Tai Te Wu, Elvin A. Kabat · The Journal of Experimental Medicine · 1970 · 1.3K citations · Full text

, , +17

A humanized antibody that binds to the interleukin 2 receptor.

Cary Queen, William P. Schneider, Harold E. Selick et al. · Proceedings of the National Academy of Sciences · 1989 · 628 citations · Full text

, , +17

Structure and Mechanistic Analysis of the Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5 in Complex with Its gp41 Epitope

Gilad Ofek, Min Tang, Anna Sambor et al. · Journal of Virology · 2004 · 485 citations · Full text

, , +17

1–5 of 444

Authors

2.5K

  1. EA
    Elvin A. Kabat

    Columbia University, United States

    12 publications · 2.3K citations

    11

    h-index

  2. SR
    Stuart Rudikoff

    National Cancer Institute, United States

    9 publications · 250 citations

    9

    h-index

  3. BF
    Blas Frangione

    New York University, United States

    7 publications · 301 citations

    7

    h-index

  4. TT
    T T Wu

    Northwestern University, United States

    7 publications · 647 citations

    7

    h-index

  5. DA
    Dennis A. Carson

    University of California San Diego, United States

    7 publications · 310 citations

    7

    h-index

1–5 of 2.5K

Institutions

659

  1. National Institutes of Health

    Bethesda, United States

    20 h-index

    60 publications

    7.4K citations

  2. Inserm

    Paris, France

    14 h-index

    78 publications

    4K citations

  3. Columbia University

    New York, United States

    11 h-index

    26 publications

    4.9K citations

  4. Scripps Research Institute

    San Diego, United States

    11 h-index

    36 publications

    2.8K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    34 publications

    1.8K citations

  6. Institut Pasteur

    Paris, France

    10 h-index

    40 publications

    2.3K citations

  7. Harvard University

    Cambridge, United States

    10 h-index

    36 publications

    2.2K citations

  8. National Cancer Institute

    Bethesda, United States

    10 h-index

    24 publications

    1.3K citations

1–8 of 659

Venues

  1. The Journal of Immunology

    JI · 94 publications · 5.3K citations

    46

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 40 publications · 3.9K citations

    31

    h-index

  3. mAbs

    18 publications · 873 citations

    17

    h-index

  4. PubMed

    Repository · 16 publications · 2.2K citations

    12

    h-index

  5. Journal of Molecular Biology

    JMB · 11 publications · 966 citations

    11

    h-index

1–5