C‐terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes

Lawrence W. Dick, Difei Qiu, David Mahon, +2

Biotechnology and Bioengineering

Immunocytochemical TechniqueImmunologyPathologyImmunotherapyHuman Monoclonal Antibodies +17

Determination of the origin of the N‐terminal pyro‐glutamate variation in monoclonal antibodies using model peptides

Lawrence W. Dick, Catherine Kim, Difei Qiu, +1

Biotechnology and Bioengineering

Peptide mapping of therapeutic monoclonal antibodies: Improvements for increased speed and fewer artifacts

Lawrence W. Dick, David Mahon, Difei Qiu, +1

Journal of Chromatography B

Systems BiologyImmunocytochemical TechniqueAutoimmune DiseaseTherapeutic Monoclonal AntibodiesMedicine +13

Aptamer-Enhanced Laser Desorption/Ionization for Affinity Mass Spectrometry

Lawrence W. Dick, Linda B. McGown

Analytical Chemistry

EngineeringThrombin-binding Dna AptamerBiological Mass SpectrometryMolecular BiologyAffinity Mass Spectrometry +14

Affinity Capture and Detection of Immunoglobulin E in Human Serum Using an Aptamer-Modified Surface in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Jacquelyn R. Cole, Lawrence W. Dick, Elizabeth J. Morgan, +1

Analytical Chemistry

Immunocytochemical TechniqueEngineeringImmunologyImmunotherapyProtein Purification +15

Soluble Human Cytomegalovirus gH/gL/pUL128–131 Pentameric Complex, but Not gH/gL, Inhibits Viral Entry to Epithelial Cells and Presents Dominant Native Neutralizing Epitopes

John W. Loughney, Richard R. Rustandi, Dai Wang, +12

Journal of Biological Chemistry

A simple reversed phase high-performance liquid chromatography method for polysorbate 80 quantitation in monoclonal antibody drug products

Michael Adamo, Lawrence W. Dick, Difei Qiu, +3

Journal of Chromatography B

Medicinal ChemistryEngineeringPolysorbate 80MedicineBioanalysis +9

Identification and measurement of isoaspartic acid formation in the complementarity determining region of a fully human monoclonal antibody

Lawrence W. Dick, Difei Qiu, Kuang‐Chuan Cheng

Journal of Chromatography B

ImmunohematologyImmunocytochemical TechniqueBiochemistryHuman Monoclonal AntibodyBioanalysis +11

Isomerization in the CDR2 of a monoclonal antibody: Binding analysis and factors that influence the isomerization rate

Lawrence W. Dick, Difei Qiu, Rosie B. Wong, +1

Biotechnology and Bioengineering

Immunocytochemical TechniqueImmunologyMolecular BiologyImmunodominanceImmunotherapy +18

Evaluation of oligosaccharide methods for carbohydrate analysis in a fully human monoclonal antibody and comparison of the results to the monosaccharide composition determination by a novel calculation

Michael Adamo, Difei Qiu, Lawrence W. Dick, +2

Journal of Pharmaceutical and Biomedical Analysis

EngineeringImmunologyGlycobiologyPolysaccharideHuman Monoclonal Antibody +14