Concepedia

Charge Variant Separation

Charge Variant Separation is a chromatographic separation technique that resolves antibody isoforms based on differences in their net surface charge, enabling the isolation of charge heterogeneity variants arising from post-translational modifications such as deamidation, isomerization, or sialylation.

78

Publications

3.8K

Citations

360

Authors

102

Institutions

Publications per year

2017–2026

47

Parents

Publications

78

Determination of isoelectric points and relative charge variants of 23 therapeutic monoclonal antibodies

Alexandre Goyon, Mélissa Excoffier, Marie-Claire Janin-Bussat et al. · Journal of Chromatography B · 2017 · 220 citations

, , +14

Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part I: Salt gradient approach

Szabolcs Fekete, Alain Beck, Jenő Fekete et al. · Journal of Pharmaceutical and Biomedical Analysis · 2014 · 181 citations

, , +17

Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part II: pH gradient approach

Szabolcs Fekete, Alain Beck, Jenő Fekete et al. · Journal of Pharmaceutical and Biomedical Analysis · 2014 · 140 citations

, , +17

Charge Variant Analysis of Monoclonal Antibodies Using Direct Coupled pH Gradient Cation Exchange Chromatography to High-Resolution Native Mass Spectrometry

Florian Füssl, Ken Cook, Kai Scheffler et al. · Analytical Chemistry · 2018 · 131 citations

, , +17

Integrated Microfluidic Capillary Electrophoresis-Electrospray Ionization Devices with Online MS Detection for the Separation and Characterization of Intact Monoclonal Antibody Variants

Erin A. Redman, Nicholas G. Batz, J. Scott Mellors et al. · Analytical Chemistry · 2015 · 127 citations

, , +16

1–5 of 78

Authors

360

  1. DG
    Davy Guillarme

    University of Geneva, Switzerland

    7 publications · 644 citations

    7

    h-index

  2. AB
    Alain Beck

    Center of Immunology Pierre Fabre, France

    7 publications · 650 citations

    7

    h-index

  3. AS
    Anurag S. Rathore

    Indian Institute of Technology Delhi, India

    5 publications · 205 citations

    5

    h-index

  4. SF
    Szabolcs Fekete

    University of Geneva, Switzerland

    5 publications · 583 citations

    5

    h-index

  5. VK
    Vijesh Kumar

    Indian Institute of Technology Delhi, India

    4 publications · 210 citations

    4

    h-index

1–5 of 360

Institutions

102

  1. Center of Immunology Pierre Fabre

    Saint-Julien-en-Genevois, France

    7 h-index

    12 publications

    1.2K citations

  2. University of Geneva

    Geneva, Switzerland

    7 h-index

    19 publications

    1.8K citations

  3. Pfizer (United States)

    New York, United States

    6 h-index

    21 publications

    1.6K citations

  4. Roche (Switzerland)

    Basel, Switzerland

    6 h-index

    19 publications

    427 citations

  5. Indian Institute of Technology Delhi

    New Delhi, India

    5 h-index

    16 publications

    603 citations

  6. University of Lausanne

    Lausanne, Switzerland

    5 h-index

    14 publications

    1.5K citations

  7. Bristol-Myers Squibb (United States)

    New York, United States

    5 h-index

    19 publications

    620 citations

  8. Regeneron (United States)

    Tarrytown, United States

    4 h-index

    22 publications

    970 citations

1–8 of 102

Venues

  1. Analytical Chemistry

    15 publications · 1.1K citations

    15

    h-index

  2. Journal of Chromatography A

    14 publications · 507 citations

    14

    h-index

  3. Electrophoresis

    8 publications · 320 citations

    8

    h-index

  4. 5

    h-index

  5. mAbs

    5 publications · 280 citations

    5

    h-index

1–5