Molecular Therapy · 2022 · 96 citations · 14 references
Life SciencesBiotechnologyMolecular BiologyGenetic EngineeringGenome EditingGenome EngineeringCrispr-cas SystemsDelivery Systems For Genome EditingGuide Rna DesignPrime EditingAdeno-associated Viral VectorsCodon OptimizationCrispr-cas9 Genome EditingEditing Efficiency OptimizationGenome Editing Via Viral VectorsGuide Rna-directed EditingTrimmingVariant Screening
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Search-and-replace genome editing without double-strand breaks or donor DNA
Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis et al. · Nature · 2019 · 4.7K citations · Full text
Effect of Genome Size on AAV Vector Packaging
Zhijian Wu, Hongyan Yang, Peter Colosi · Molecular Therapy · 2009 · 972 citations · Full text
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
Daniel P. Dever, Rasmus O. Bak, Andreas Reinisch et al. · Nature · 2016 · 876 citations · Full text
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
Peter J. Chen, Jeffrey A. Hussmann, Jun Yan et al. · Cell · 2021 · 799 citations · Full text
Engineered pegRNAs improve prime editing efficiency
James W. Nelson, Peyton B. Randolph, Simon P. Shen et al. · Nature Biotechnology · 2021 · 717 citations · Full text