Concepedia

Editing Efficiency Optimization

Editing Efficiency Optimization is a methodological framework within base editing research that systematically enhances the precision, specificity, and yield of targeted nucleotide modifications by refining experimental parameters, molecular components, and delivery strategies to maximize desired editing outcomes.

171

Publications

18.2K

Citations

1.3K

Authors

384

Institutions

Publications per year

2017–2026

156

Parents

Publications

171

A TALE nuclease architecture for efficient genome editing

Jeffrey C. Miller, Siyuan Tan, Guijuan Qiao et al. · Nature Biotechnology · 2010 · 2.1K citations

, , +14

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

Michelle F. Richter, Kevin T. Zhao, Elliot O. Eton et al. · Nature Biotechnology · 2020 · 1K citations · Full text

, , +9

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

Luke W. Koblan, Jordan L. Doman, Christopher Wilson et al. · Nature Biotechnology · 2018 · 984 citations · Full text

, , +14

In vivo genome editing using a high-efficiency TALEN system

Victoria M. Bedell, Ying Wang, Jarryd M. Campbell et al. · Nature · 2012 · 920 citations · Full text

, , +13

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

Alexis C. Komor, Kevin T. Zhao, Michael S. Packer et al. · Science Advances · 2017 · 784 citations · Full text

, , +16

1–5 of 171

Authors

1.3K

  1. DR
    David R. Liu

    Harvard University, United States

    12 publications · 4.7K citations

    12

    h-index

  2. XH
    Xingxu Huang

    ShanghaiTech University, China

    7 publications · 590 citations

    7

    h-index

  3. GA
    Gregory A. Newby

    Howard Hughes Medical Institute, United States

    7 publications · 3K citations

    7

    h-index

  4. CB
    Changhao Bi

    Tianjin Institute of Industrial Biotechnology, China

    6 publications · 200 citations

    6

    h-index

  5. JL
    Jordan L. Doman

    Broad Institute, United States

    6 publications · 2.3K citations

    6

    h-index

1–5 of 1.3K

Institutions

384

  1. Chinese Academy of Sciences

    Beijing, China

    22 h-index

    142 publications

    11K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    98 publications

    40.8K citations

  3. Harvard University

    Cambridge, United States

    16 h-index

    124 publications

    41.4K citations

  4. Broad Institute

    Cambridge, United States

    15 h-index

    90 publications

    36.9K citations

  5. University of Chinese Academy of Sciences

    Beijing, China

    13 h-index

    68 publications

    7.1K citations

  6. ShanghaiTech University

    Shanghai, China

    10 h-index

    64 publications

    6.3K citations

  7. Tianjin Institute of Industrial Biotechnology

    Tianjin, China

    8 h-index

    56 publications

    2K citations

  8. Harvard University Press

    Cambridge, United States

    8 h-index

    8 publications

    2.5K citations

1–8 of 384

Venues

  1. Nature Biotechnology

    19 publications · 7.8K citations

    19

    h-index

  2. Nature Communications

    19 publications · 1.3K citations

    19

    h-index

  3. Nucleic Acids Research

    11 publications · 571 citations

    11

    h-index

  4. Molecular Therapy — Nucleic Acids

    6 publications · 150 citations

    6

    h-index

  5. Nature Chemical Biology

    5 publications · 263 citations

    5

    h-index

1–5