Luke W. Koblan

Search-and-replace genome editing without double-strand breaks or donor DNA

Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis et al. · Nature · 2019 · 4.7K citations · Full text

Life Sciences, Genetics, Molecular Biology +9

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

Michelle F. Richter, Kevin T. Zhao, Elliot O. Eton et al. · Nature Biotechnology · 2020 · 1K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +9

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

Luke W. Koblan, Jordan L. Doman, Christopher Wilson et al. · Nature Biotechnology · 2018 · 984 citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +14

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

Alexis C. Komor, Kevin T. Zhao, Michael S. Packer et al. · Science Advances · 2017 · 784 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing

Andrew V. Anzalone, Xin D. Gao, Christopher J. Podracky et al. · Nature Biotechnology · 2021 · 573 citations · Full text

Life Sciences, Genetics, Molecular Biology +11