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Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies

Medicinal ChemistryCyclooxygenase InhibitionMedicinePyrazole-based CompoundsRational Drug DesignPharmacological AgentPharmacotherapyAnti-cancer AgentDrug Development1,2,4-Triazole-3-thiol MoietyPharmacologyPharmaceutical ChemistryDrug Discovery