Emad H. M. Hassanein

The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity

Emad H. M. Hassanein, Abdel‐Gawad S. Shalkami, Marwa M. Khalaf et al. · Biomedicine & Pharmacotherapy · 2018 · 113 citations · Full text

New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies

Wael A. A. Fadaly, Yaseen A. M. M. Elshaier, Emad H. M. Hassanein et al. · Bioorganic Chemistry · 2020 · 85 citations

Medicinal Chemistry, Biochemistry, Donor Celecoxib Analogs +11

Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P38MAPK/NF-κB, and apoptosis signaling pathways

Emad H. M. Hassanein, Wafaa R. Mohamed, Abdel‐Gawad S. Shalkami et al. · Food and Chemical Toxicology · 2018 · 70 citations

Apoptosis, Renal Inflammation, Cell Death +16

Coenzyme Q10 protects hepatocytes from ischemia reperfusion-induced apoptosis and oxidative stress via regulation of Bax/Bcl-2/PUMA and Nrf-2/FOXO-3/Sirt-1 signaling pathways

Amany Refaat Mahmoud, Fares E.M. Ali, Tarek Hamdy Abd‐Elhamid et al. · Tissue and Cell · 2019 · 61 citations

Inflammation, Hepatology, Coenzyme Q10 +12

Agomelatine prevents gentamicin nephrotoxicity by attenuating oxidative stress and TLR-4 signaling, and upregulating PPARγ and SIRT1

Ayman M. Mahmoud, Omnia A. M. Abd El‐Ghafar, Mohammed A. Alzoghaibi et al. · Life Sciences · 2021 · 54 citations

Inflammation, Agomelatine Prevents, Redox Signaling +11