John N. Philoppes

Azole-hydrazone derivatives: Design, synthesis, in vitro biological evaluation, dual EGFR/HER2 inhibitory activity, cell cycle analysis and molecular docking study as anticancer agents

Madlen B. Labib, John N. Philoppes, Phoebe F. Lamie et al. · Bioorganic Chemistry · 2017 · 85 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study

Phoebe F. Lamie, John N. Philoppes, Amany A. Azouz et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Design and synthesis of new benzoxazole/benzothiazole-phthalimide hybrids as antitumor-apoptotic agents

John N. Philoppes, Phoebe F. Lamie · Bioorganic Chemistry · 2019 · 62 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structure–activity relationship and biological activity as potential antitumor and anticonvulsant agents

Phoebe F. Lamie, Asmaa M. El-Kalaawy, N. LATIF et al. · European Journal of Medicinal Chemistry · 2021 · 49 citations · Full text

Medicine, Medicinal Chemistry, Oncology +16

Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies

Khaled R.A. Abdellatif, Eman K. A. Abdelall, Heba A.H. Elshemy et al. · Bioorganic Chemistry · 2021 · 49 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17