Nesma M. Kahk

Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies

Khaled R.A. Abdellatif, Eman K. A. Abdelall, Heba A.H. Elshemy et al. · Bioorganic Chemistry · 2021 · 47 citations

Medicinal Chemistry, Cyclooxygenase Inhibition, Medicine +10

Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities

Wael A. A. Fadaly, Mohamed T. M. Nemr, Nesma M. Kahk · Bioorganic Chemistry · 2024 · 44 citations

Medicinal Chemistry, Urology, Novel Pyrazole +11

New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and ADME studies

Wael A. A. Fadaly, Taha H. Zidan, Nesma M. Kahk et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2023 · 37 citations · Full text

Discovery of novel thiazole derivatives containing pyrazole scaffold as PPAR-γ Agonists, α-Glucosidase, α-Amylase and COX-2 inhibitors; Design, synthesis and in silico study

Wael A. A. Fadaly, Ahmed Elshewy, Mohamed T. M. Nemr et al. · Bioorganic Chemistry · 2024 · 30 citations

Medicinal Chemistry, Biochemistry, Cox-2 Inhibitors +9

Design, Synthesis, Antioxidant and Anticancer Activity of New Coumarin Derivatives Linked with Thiazole, Isoxazole or Pyrazole Moiety

Khaled R.A. Abdellatif, Mohamed A. Abdelgawad, Heba A.H. Elshemy et al. · Letters in Drug Design & Discovery · 2017 · 18 citations