Raman spectroscopy for in situ, real time monitoring of protein aggregation in lyophilized biotherapeutic products

Challenges in the development of high protein concentration formulations

Zahra Shahrokh, Jun 军 Liu 刘 · Journal of Pharmaceutical Sciences · 2004 · 879 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +12

Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

John den Engelsman, Patrick Garidel, Ronald Smulders et al. · Pharmaceutical Research · 2010 · 350 citations · Full text

Life Sciences, Biotechnology, Pharmaceutical Biotechnology +17

Immunogenicity of aggregates of recombinant human growth hormone in mouse models

Amber Haynes Fradkin, John F. Carpenter, Theodore W. Randolph · Journal of Pharmaceutical Sciences · 2009 · 169 citations · Full text

Life Sciences, Endocrinology, Immunology +10

Discrimination between authentic and counterfeit banknotes using Raman spectroscopy and PLS-DA with uncertainty estimation

Mariana Ramos Almeida, Deleon Nascimento Correa, Wérickson Fortunato de Carvalho Rocha et al. · Microchemical Journal · 2012 · 143 citations

Natural Sciences, Chemistry, Authentication +16

Raman Spectroscopic Characterization of Drying-Induced Structural Changes in a Therapeutic Antibody: Correlating Structural Changes with Long-Term Stability

Samir U. Sane, Rita Wong, Chung C. Hsu · Journal of Pharmaceutical Sciences · 2004 · 107 citations

Pharmacy, Biochemistry, Biophysics +17