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Serine restriction alters sphingolipid diversity to constrain tumour growth

Thangaselvam Muthusamy, Thekla Cordes, Michal K. Handzlik, Le You, Esther W. Lim, Jivani M. Gengatharan, Antônio F. M. Pinto, Mehmet G. Badur, Matthew J. Kolar, Martina Wallace,

Nature · 2020 · 314 citations · 35 references

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35

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Richard Possemato, Kevin M. Marks, Yoav D. Shaul et al. · Nature · 2011 · 1.7K citations · Full text

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Jason W. Locasale, Alexandra Grassian, Tamar Melman et al. · Nature Genetics · 2011 · 1.1K citations · Full text

, , +13

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

Zachary T. Schafer, Alexandra Grassian, Loling Song et al. · Nature · 2009 · 1K citations · Full text

, , +16

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Oliver D.K. Maddocks, Celia R. Berkers, Susan Mason et al. · Nature · 2012 · 1K citations

, , +16

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Oliver D.K. Maddocks, Dimitris Athineos, Eric C. Cheung et al. · Nature · 2017 · 619 citations

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