Concepedia

Sphingolipid Biosynthesis

Sphingolipid Biosynthesis is a metabolic pathway within lipid biosynthesis that specifically governs the de novo formation of sphingolipids through the sequential enzymatic assembly of a sphingoid base backbone and subsequent addition of acyl and head groups, distinguishing it from other lipid classes by its characteristic ceramide core structure and roles in membrane biogenesis and signaling.

2.4K

Publications

148.6K

Citations

9.6K

Authors

2K

Institutions

Publications per year

2017–2026

428

Parents

Publications

2.4K

The sphingomyelin cycle and the second messenger function of ceramide.

Yusuf A. Hannun · Journal of Biological Chemistry · 1994 · 1.3K citations · Full text

, , +14

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

E Wang, William P. Norred, Charles W. Bacon et al. · Journal of Biological Chemistry · 1991 · 1.1K citations · Full text

, , +11

Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism.

Sen‐itiroh Hakomori · PubMed · 1996 · 995 citations

, , +17

The HIV lipidome: A raft with an unusual composition

Britta Brügger, Bärbel Glass, Per Haberkant et al. · Proceedings of the National Academy of Sciences · 2006 · 695 citations · Full text

, , +17

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

H Zhang, Naishadh Desai, Ana Olivera et al. · The Journal of Cell Biology · 1991 · 651 citations · Full text

, , +15

1–5 of 2.4K

Authors

9.6K

  1. YA
    Yusuf A. Hannun

    Medical University of South Carolina, United States

    101 publications · 9.7K citations

    52

    h-index

  2. AH
    Alfred H. Merrill

    Emory University, United States

    63 publications · 8.4K citations

    48

    h-index

  3. KH
    Kentaro Hanada

    National Institute of Infectious Diseases, Japan

    39 publications · 3K citations

    30

    h-index

  4. AH
    Anthony H. Futerman

    Weizmann Institute of Science, Israel

    39 publications · 3.8K citations

    28

    h-index

  5. LM
    Lina M. Obeid

    Medical University of South Carolina, United States

    40 publications · 3.5K citations

    28

    h-index

1–5 of 9.6K

Institutions

2K

  1. Medical University of South Carolina

    Charleston, United States

    60 h-index

    470 publications

    41.5K citations

  2. University of Kentucky

    Lexington, United States

    34 h-index

    168 publications

    17.4K citations

  3. National Institutes of Health

    Bethesda, United States

    33 h-index

    205 publications

    15.4K citations

  4. Inserm

    Paris, France

    33 h-index

    250 publications

    13.4K citations

  5. Emory University

    Atlanta, United States

    32 h-index

    125 publications

    17K citations

  6. Georgia Institute of Technology

    Atlanta, United States

    30 h-index

    102 publications

    12.7K citations

  7. University of Bonn

    Bonn, Germany

    30 h-index

    187 publications

    15.2K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    30 h-index

    221 publications

    11.7K citations

1–8 of 2K

Venues

  1. Journal of Biological Chemistry

    JBC · 329 publications · 37K citations

    114

    h-index

  2. Journal of Lipid Research

    JLR · 133 publications · 6.7K citations

    48

    h-index

  3. Biochemical Journal

    BJ · 49 publications · 3.3K citations

    33

    h-index

  4. 31

    h-index

  5. PubMed

    Repository · 51 publications · 4K citations

    28

    h-index

1–5