Jason W. Locasale

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Haoqiang Ying, Alec C. Kimmelman, Costas A. Lyssiotis et al. · Cell · 2012 · 2K citations · Full text

Pancreatic Cancer, Oncogenic Agent, Medicine +7

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ping‐Chih Ho, Jessica Bihuniak, Andrew N. Macintyre et al. · Cell · 2015 · 1.4K citations · Full text

Energy Metabolism, Signal Transduction, Biochemistry +12

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Dimitrios Anastasiou, George Poulogiannis, John M. Asara et al. · Science · 2011 · 1.2K citations · Full text

Lipid Peroxidation, Cell Death, Metabolic Remodeling +19

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Jason W. Locasale, Alexandra Grassian, Tamar Melman et al. · Nature Genetics · 2011 · 1.1K citations · Full text

Biochemistry, Phosphoglycerate Dehydrogenase, Catabolism +4

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Valerie A. Gerriets, Rigel J. Kishton, Amanda Nichols et al. · Journal of Clinical Investigation · 2014 · 699 citations · Full text

Treg Subsets, Adaptive Immune System, Metabolic Programming +21