Dimitrios Anastasiou

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Dimitrios Anastasiou, George Poulogiannis, John M. Asara et al. · Science · 2011 · 1.2K citations · Full text

Lipid Peroxidation, Cell Death, Metabolic Remodeling +19

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Jason W. Locasale, Alexandra Grassian, Tamar Melman et al. · Nature Genetics · 2011 · 1.1K citations · Full text

Biochemistry, Phosphoglycerate Dehydrogenase, Catabolism +4

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen et al. · Nature Chemical Biology · 2012 · 804 citations · Full text

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

Isabel García‐Cao, Min Sup Song, Robin M. Hobbs et al. · Cell · 2012 · 398 citations · Full text

Systemic Elevation, Metabolic Regulation, Metabolic Remodeling +4

mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

Demetrios Kalaitzidis, Stephen M. Sykes, Zhu Wang et al. · Cell stem cell · 2012 · 195 citations · Full text

Hematological Malignancy, Mtor Complex 1, Signal Transduction +11