William J. Israelsen

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Eva M. Pålsson‐McDermott, Annie M. Curtis, Gautam Goel et al. · Cell Metabolism · 2015 · 1.3K citations · Full text

Inflammation, Cytokine, Pyruvate Kinase M2 +10

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen et al. · Nature Chemical Biology · 2012 · 804 citations · Full text

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

William J. Israelsen, Talya L. Dayton, Shawn M. Davidson et al. · Cell · 2013 · 539 citations · Full text

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

Weier Qi, Hillary A. Keenan, Qian Li et al. · Nature Medicine · 2017 · 479 citations · Full text

Metabolic Syndrome, Biochemistry, Mitochondrial Function +14

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

Yinghua Wang, William J. Israelsen, Dongjun Lee et al. · Cell · 2014 · 346 citations · Full text

Hematological Malignancy, Hematology, Blood Cell +5