William J. Israelsen

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Publications

Citations

4.3K

H-Index

Active since

2011

Affiliations

Massachusetts Institute of Technology(Current)

Dana-Farber Cancer Institute

Harvard University

Beth Israel Deaconess Medical Center

The University of Texas Southwestern Medical Center

William J. Israelsen is an author at Massachusetts Institute of Technology specializing in pyruvate kinase regulation, metabolic reprogramming, and life sciences.

ORCID

Publications per year

2011–2022

Publications

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Eva M. Pålsson‐McDermott, Annie M. Curtis, Gautam Goel et al. · Cell Metabolism · 2015 · 1.4K citations · Full text

Life Sciences, Biochemistry, Immunology +16

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen et al. · Nature Chemical Biology · 2012 · 825 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +15

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

William J. Israelsen, Talya L. Dayton, Shawn M. Davidson et al. · Cell · 2013 · 550 citations · Full text

Medicine, Molecular Biology, Oncology +17

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

Weier Qi, Hillary A. Keenan, Qian Li et al. · Nature Medicine · 2017 · 493 citations

Medicine, Biochemistry, Nephrology +15

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

Yinghua Wang, William J. Israelsen, Dongjun Lee et al. · Cell · 2014 · 351 citations · Full text

Life Sciences, Cell Biology, Hematology +12

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