Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

Tumor Biology, Medicine, Molecular Biology +9

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

Gregg L. Semenza, Bing‐Hua Jiang, Sandra W. Leung et al. · Journal of Biological Chemistry · 1996 · 1.7K citations · Full text

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

Véronique Baldin, Jiří Lukáš, María Jesús Marcote et al. · Genes & Development · 1993 · 1.6K citations · Full text

Transcriptional Regulation, Cell Cycle Progression, Cell Division +15

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Valeria R. Fantin, Julie St‐Pierre, Philip Leder · Cancer Cell · 2006 · 1.6K citations · Full text

Tumor Biology, Mitochondrial Function, Biochemistry +12

Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

Andrei V. Krivtsov, David Twomey, Zhaohui Feng et al. · Nature · 2006 · 1.5K citations

Developmental Biology, Cell Division, Medicine +8