Matthew G. Vander Heiden

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang, David W. White, Bryson D. Bennett et al. · Nature · 2009 · 4K citations · Full text

Tumor Biology, Cancer-associated Idh1 Mutations, Oncogenic Agent +4

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

Tumor Biology, Medicine, Molecular Biology +9

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Katrin Düvel, Jessica L. Yecies, Suchithra Menon et al. · Molecular Cell · 2010 · 1.9K citations · Full text

Metabolic Network, Systems Biology, Signal Transduction +9

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Christian M. Metallo, Paulo A. Gameiro, Eric L. Bell et al. · Nature · 2011 · 1.7K citations · Full text

Biochemistry, Redox Regulator, Hypoxia (Medicine) +5

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Cosimo Commisso, Shawn M. Davidson, Rengin G. Soydaner-Azeloglu et al. · Nature · 2013 · 1.6K citations

Protein Function, Signal Transduction, Ras-transformed Cells +11