DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Jiřina Bártková, Zuzana Hořejšı́, Karen Koed, +10

Nature

ChromatinTumor BiologyGenome InstabilityDna DamageOncogenic Agent +9

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos, +22

Nature

Oncogene-induced SenescenceChromatinGenome InstabilityDna DamageOncogenic Agent +9

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

Véronique Baldin, Jiří Lukáš, María Jesús Marcote, +2

Genes & Development

Transcriptional RegulationCell Cycle ProgressionCell DivisionTumor MicroenvironmentCyclin D1 +13

Human CtIP promotes DNA end resection

Alessandro A. Sartori, Claudia Lukas, Julia Coates, +6

Nature

ChromatinGenome InstabilityHuman CtipDna ReplicationMedicine +2

RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

Niels Mailand, Simon Bekker‐Jensen, Helene Faustrup, +4

Cell

ChromatinGenome InstabilityRepair ProteinsDna Double-strand BreaksChromatin Remodeling +6

The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Jacob Falck, Niels Mailand, Randi G. Syljuåsen, +2

Nature

Genome InstabilityNatural SciencesDna ReplicationMolecular BiologyRadioresistant Dna Synthesis +3

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Ali Jazayeri, Jacob Falck, Claudia Lukas, +4

Nature Cell Biology

ChromatinGenome InstabilityTranscriptional RegulationDna DamageCell Division +11

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

Luis Toledo, Matthias Altmeyer, Maj‐Britt Rask, +7

Cell

Data ReplicationGlobal ExhaustionDna ReplicationSystems Biology

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

Carsten Doil, Niels Mailand, Simon Bekker‐Jensen, +9

Cell

ChromatinGenome InstabilityChromosome DynamicsRepair ProteinsProtein Function +8

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

Jiří Lukáš, David Parry, Louise Aagaard, +4

Nature

Tumor BiologyCell RegulationRetinoblastoma-protein-dependent Cell-cycle InhibitionCell CycleTumor Suppressor +4