Andrei V. Krivtsov

Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

Andrei V. Krivtsov, David Twomey, Zhaohui Feng et al. · Nature · 2006 · 1.5K citations

Developmental Biology, Cell Division, Medicine +8

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

Kathrin M. Bernt, Nan Zhu, Amit Sinha et al. · Cancer Cell · 2011 · 883 citations · Full text

Hematological Malignancy, Tumor Biology, Chromatin +9

The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

Andrei V. Krivtsov, Amit Sinha, Trista E. North et al. · Science · 2010 · 741 citations

Hematological Malignancy, Developmental Biology, Limitless Self-renewal +15

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

Andrei V. Krivtsov, Zhaohui Feng, Madeleine E. Lemieux et al. · Cancer Cell · 2008 · 547 citations · Full text

Chromatin, Epigenetic Change, Dna Methylation +6

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

Eytan M. Stein, Guillermo Garcia‐Manero, David A. Rizzieri et al. · Blood · 2018 · 442 citations · Full text