Madeleine E. Lemieux

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake Delmore, Ghayas C. Issa, Madeleine E. Lemieux et al. · Cell · 2011 · 2.8K citations · Full text

Medicine, Immunology, Therapeutic Efficacy +7

Mammalian SIRT1 Represses Forkhead Transcription Factors

Maria Carla Motta, Nullin Divecha, Madeleine E. Lemieux et al. · Cell · 2004 · 1.3K citations · Full text

Transcriptional Regulation, Genetics, Gene Regulation +4

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Laura Bordone, Maria Carla Motta, Frédéric Picard et al. · PLoS Biology · 2005 · 702 citations · Full text

Insulin Signaling, Metabolic Syndrome, Signaling Pathway +16

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

Boris G. Wilson, Xi Wang, Xiaohua Shen et al. · Cancer Cell · 2010 · 633 citations · Full text

Chromatin, Chromatin Remodeling, Epigenetic Change +9

The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

Michael W. McBurney, Xiaofeng Yang, Karen Jardine et al. · Molecular and Cellular Biology · 2002 · 616 citations · Full text

Genetics, Genomic Mechanism, Yeast Sir2p Protein +19