Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

Joy Hsu, Jonathan J. Hodgins, Malvika Marathe, +16

Journal of Clinical Investigation

ImmunologyNk CellsImmunologic MechanismImmune Cell TherapyImmunotherapy +15

The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

Michael W. McBurney, Xiaofeng Yang, Karen Jardine, +5

Molecular and Cellular Biology

GeneticsGenomic MechanismYeast Sir2p ProteinMolecular GeneticsEpigenetics +17

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

Gino Boily, Erin L. Seifert, Lisa Bevilacqua, +11

PLoS ONE

GeneticsCaloric RestrictionOxidative StressObesityMetabolic Syndrome +19

The mouse Pgk-1 gene promoter contains an upstream activator sequence

Michael W. McBurney, Leslie C. Sutherland, Chakar N. Adra, +3

Nucleic Acids Research

Pgk-1 GeneTranscriptional RegulationSystems BiologyFunctional GenomicsProtein Expression +11

SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol

Gino Boily, Xiaohui He, Brenda Pearce, +2

Oncogene

Oncogenic AgentMedicineNormal RatesPathologyCancer Biology +5

sirt1-null mice develop an autoimmune-like condition

Jedon Sequeira, Gino Boily, Stephanie Bazinet, +8

Experimental Cell Research

ImmunogeneticsAutoimmune DiseaseSirt1-null MiceImmunologyAutoimmunity +5

The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals

Madeleine E. Lemieux, Xi Yang, Karen Jardine, +5

Mechanisms of Ageing and Development

Developmental BiologySignaling PathwayInsulin-like Growth FactorGrowth HormoneDiabetes +9

Polymorphisms in the coding and noncoding regions of murinePgk-1 alleles

Poppo H. Boer, Holger Potten, Chaker N. Adra, +3

Biochemical Genetics

Genetic AnalysisAllelic VariantGenotype-phenotype AssociationGeneticsHuman Polymorphism +5

Evidence for Repeat-Induced Gene Silencing in Cultured Mammalian Cells: Inactivation of Tandem Repeats of Transfected Genes

Michael W. McBurney, Tina Mai, Xiaofeng Yang, +1

Experimental Cell Research

Genome InstabilityGeneticsTransfected GenesRepeat-induced Gene SilencingTandem Repeats +4

The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome

Annabelle Z. Caron, Xiaohong He, Walid Mottawea, +7

The FASEB Journal

Sirt1 GenotypeMetabolic DisorderHost-microbe InteractionsInsulin SignalingObesity +17