Costas A. Lyssiotis

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Haoqiang Ying, Alec C. Kimmelman, Costas A. Lyssiotis et al. · Cell · 2012 · 2K citations · Full text

Pancreatic Cancer, Oncogenic Agent, Medicine +7

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son, Costas A. Lyssiotis, Haoqiang Ying et al. · Nature · 2013 · 1.9K citations · Full text

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Michael A. Badgley, Daniel M. Kremer, H. Carlo Maurer et al. · Science · 2020 · 1.2K citations · Full text

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Andrea Viale, Piergiorgio Pettazzoni, Costas A. Lyssiotis et al. · Nature · 2014 · 1.2K citations · Full text

Pancreatic Cancer, Mitochondrial Function, Medicine +3

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Jason W. Locasale, Alexandra Grassian, Tamar Melman et al. · Nature Genetics · 2011 · 1.1K citations · Full text

Biochemistry, Phosphoglycerate Dehydrogenase, Catabolism +4