Concepedia

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son, Costas A. Lyssiotis, Haoqiang Ying, Xiaoxu Wang, Sujun Hua, Matteo Ligorio, Rushika M. Perera, Cristina R. Ferrone, Edouard Mullarky, Ng Shyh‐Chang,

Nature · 2013 · 2K citations · 15 references

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15

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Ralph J. DeBerardinis, Anthony Mancuso, Evgueni Daikhin et al. · Proceedings of the National Academy of Sciences · 2007 · 2.6K citations · Full text

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Gina M. DeNicola, Florian A. Karreth, Timothy J. Humpton et al. · Nature · 2011 · 2.2K citations · Full text

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Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Haoqiang Ying, Alec C. Kimmelman, Costas A. Lyssiotis et al. · Cell · 2012 · 2K citations · Full text

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

David R. Wise, Ralph J. DeBerardinis, Anthony Mancuso et al. · Proceedings of the National Academy of Sciences · 2008 · 2K citations · Full text

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Frank Weinberg, Robert B. Hamanaka, William W. Wheaton et al. · Proceedings of the National Academy of Sciences · 2010 · 1.7K citations

, , +17