Edouard Mullarky

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son, Costas A. Lyssiotis, Haoqiang Ying et al. · Nature · 2013 · 1.9K citations · Full text

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Jason W. Locasale, Alexandra Grassian, Tamar Melman et al. · Nature Genetics · 2011 · 1.1K citations · Full text

Biochemistry, Phosphoglycerate Dehydrogenase, Catabolism +4

Vitamin C selectively kills <i>KRAS</i> and <i>BRAF</i> mutant colorectal cancer cells by targeting GAPDH

Jihye Yun, Edouard Mullarky, Changyuan Lu et al. · Science · 2015 · 896 citations

NRF2 regulates serine biosynthesis in non–small cell lung cancer

Gina M. DeNicola, Pei-Hsuan Chen, Edouard Mullarky et al. · Nature Genetics · 2015 · 763 citations · Full text

Tumor Biology, Medicine, Cancer Cell Biology +5

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Edouard Mullarky, Natasha C. Lucki, Reza Beheshti Zavareh et al. · Proceedings of the National Academy of Sciences · 2016 · 331 citations · Full text

Engineering, Aldo-keto Reductase, Small Molecule Inhibitor +20