Concepedia

Glutamine Synthesis

Glutamine Synthesis is a metabolic pathway distinct from general amino acid metabolism in that it specifically involves the ATP-dependent conversion of glutamate and ammonia into glutamine, primarily mediated by glutamine synthetase in glial cells to maintain nitrogen homeostasis and support neurotransmitter cycling in the central nervous system.

3.3K

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188.4K

Citations

11K

Authors

2.2K

Institutions

Publications per year

2017–2026

365

Parents

Publications

3.3K

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Ping Gao, Irina Tchernyshyov, Tsung-Cheng Chang et al. · Nature · 2009 · 2.1K citations · Full text

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son, Costas A. Lyssiotis, Haoqiang Ying et al. · Nature · 2013 · 2K citations · Full text

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Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Yoichiro Mitsuishi, Keiko Taguchi, Yukie Kawatani et al. · Cancer Cell · 2012 · 1.4K citations · Full text

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Fine structural localization of glutamine synthetase in astrocytes of rat brain

Michael D. Norenberg, Antonio Martinez-Hernandez · Brain Research · 1979 · 1.3K citations

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Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

Larry Reitzer, Burton M. Wice, David Kennell · Journal of Biological Chemistry · 1979 · 1.2K citations · Full text

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1–5 of 3.3K

Authors

11K

  1. JM
    John M. Buchanan

    Massachusetts Institute of Technology, United States

    38 publications · 2.5K citations

    34

    h-index

  2. BM
    Boris Magasanik

    Massachusetts Institute of Technology, United States

    30 publications · 2.6K citations

    26

    h-index

  3. AM
    Alton Meister

    Cornell University, United States

    30 publications · 2.9K citations

    25

    h-index

  4. ER
    Earl R. Stadtman

    National Heart Lung and Blood Institute, United States

    30 publications · 3.4K citations

    23

    h-index

  5. BH
    Bertrand Hirel

    Département Santé des Plantes et Environnement, France

    24 publications · 1.4K citations

    22

    h-index

1–5 of 11K

Institutions

2.2K

  1. Massachusetts Institute of Technology

    Cambridge, United States

    42 h-index

    190 publications

    24.1K citations

  2. National Institutes of Health

    Bethesda, United States

    39 h-index

    167 publications

    12.4K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    35 h-index

    269 publications

    21.6K citations

  4. Harvard University

    Cambridge, United States

    34 h-index

    223 publications

    32K citations

  5. Cornell University

    Ithaca, United States

    31 h-index

    124 publications

    10.6K citations

  6. University of Pennsylvania

    Philadelphia, United States

    31 h-index

    124 publications

    13.8K citations

  7. University of Oxford

    Oxford, United Kingdom

    30 h-index

    117 publications

    7.4K citations

  8. National Heart Lung and Blood Institute

    Bethesda, United States

    29 h-index

    111 publications

    8.6K citations

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Venues

  1. Journal of Biological Chemistry

    JBC · 212 publications · 17.4K citations

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  2. Journal of Bacteriology

    JB · 109 publications · 6.6K citations

    51

    h-index

  3. Journal of Neurochemistry

    JNC · 102 publications · 6.9K citations

    48

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 50 publications · 5.4K citations

    41

    h-index

  5. PubMed

    Repository · 78 publications · 2.8K citations

    34

    h-index

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