Esther W. Lim

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Xiaoguang Liu, Kellen Olszewski, Yilei Zhang et al. · Nature Cell Biology · 2020 · 558 citations · Full text

Disulfide Stress, Targetable Metabolic Vulnerability, Cystine Transporter Regulation +12

Serine restriction alters sphingolipid diversity to constrain tumour growth

Thangaselvam Muthusamy, Thekla Cordes, Michal K. Handzlik et al. · Nature · 2020 · 298 citations · Full text

Malignant Disease, Medicine, Pathology +6

γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

Xue Gao, Liang Zhao, Shuangping Liu et al. · Molecular Cell · 2019 · 83 citations · Full text

Biosynthesis, Signal Transduction, Molecular Physiology +9

Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function

Brandon Gheller, Jamie Blum, Esther W. Lim et al. · Molecular Metabolism · 2020 · 68 citations · Full text

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy

Isaac Perea‐Gil, Timon Seeger, Arne A.N. Bruyneel et al. · European Heart Journal · 2022 · 63 citations · Full text