Methods in molecular biology · 2020 · 19 citations · 34 references
Life SciencesGeneticsMolecular BiologyGenetic EngineeringGenome EditingGenome EngineeringCrispr-based EngineeringCrispr-cas SystemsGuide Rna DesignNucleic Acid Drug DesignTarget Site SelectionTherapeutic Genome EditingClustered Regularly Interspaced Short Palindromic Repeats (Crispr)-based MutagenesisCrispr Guide Rna DesignCrispr-based Genome EngineeringCrispr-cas Genome EditingCrispr-cas9 Genome Editing
34
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.7K citations
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu, David A. Scott, Joshua A. Weinstein et al. · Nature Biotechnology · 2013 · 4.9K citations · Full text
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Yanfang Fu, Jennifer A Foden, Cyd Khayter et al. · Nature Biotechnology · 2013 · 3.3K citations · Full text