Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

Comprehensive Integration of Single-Cell Data

Tim Stuart, Andrew Butler, Paul Hoffman et al. · Cell · 2019 · 16K citations · Full text

Engineering, Biomedical Data Integration, Data Science +11

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler, Paul Hoffman, Peter Smibert et al. · Nature Biotechnology · 2018 · 14.1K citations · Full text

Engineering, Genetics, Multiomics +17

Near-optimal probabilistic RNA-seq quantification

Nicolas Bray, Harold Pimentel, Páll Melsted et al. · Nature Biotechnology · 2016 · 10.4K citations

Functional Genomics, Engineering, Genetics +7

UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction

Leland McInnes, John J. Healy · Deep Blue (University of Michigan) · 2018 · 7.4K citations · Full text

Geometric Modeling, Engineering, Machine Learning +15

Dimensionality reduction for visualizing single-cell data using UMAP

Étienne Becht, Leland McInnes, John Healy et al. · Nature Biotechnology · 2018 · 5.5K citations

Interactive Visualization, Engineering, Data Science +7