Concepedia

Interleukin-17 Pathway

The Interleukin-17 Pathway is a signaling cascade mediating pro-inflammatory immune responses through the activation and regulation of interleukin-17 cytokines, primarily produced by T helper 17 cells, that promotes host defense against extracellular pathogens and contributes to the pathogenesis of autoimmune diseases by inducing recruitment of immune cells and production of inflammatory mediators.

4.3K

Publications

401.8K

Citations

26.6K

Authors

3.8K

Institutions

Publications per year

2017–2026

1.5K

Variants

Il-17 Pathway

Parents

Publications

4.3K

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al. · Cell · 2006 · 5.1K citations · Full text

, , +16

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Laurie E. Harrington, Robin D. Hatton, Paul R. Mangan et al. · Nature Immunology · 2005 · 4.7K citations

, , +17

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivaylo I. Ivanov, Koji Atarashi, Nicolas Manel et al. · Cell · 2009 · 4.5K citations · Full text

, , +14

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Heon Park, Zhaoxia Li, Xuexian O. Yang et al. · Nature Immunology · 2005 · 4.2K citations · Full text

, , +17

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

Leslie van der Fits, Sabine Mourits, Jane S.A. Voerman et al. · The Journal of Immunology · 2009 · 2.1K citations · Full text

, , +17

1–5 of 4.3K

Authors

26.6K

  1. YI
    Yoichiro Iwakura

    Tokyo University of Science, Japan

    97 publications · 20.7K citations

    58

    h-index

  2. JK
    Jay K. Kolls

    University of Pittsburgh, United States

    74 publications · 15.4K citations

    56

    h-index

  3. MC
    Mi‐La Cho

    Catholic University of Korea, South Korea

    45 publications · 2.9K citations

    33

    h-index

  4. SL
    Sarah L. Gaffen

    University of Pittsburgh, United States

    36 publications · 4.4K citations

    31

    h-index

  5. XL
    Xiaoxia Li

    Cleveland Clinic, United States

    32 publications · 4.7K citations

    31

    h-index

1–5 of 26.6K

Institutions

3.8K

  1. Harvard University

    Cambridge, United States

    65 h-index

    486 publications

    108.6K citations

  2. National Institutes of Health

    Bethesda, United States

    57 h-index

    339 publications

    62K citations

  3. The University of Tokyo

    Tokyo, Japan

    53 h-index

    232 publications

    63K citations

  4. Inserm

    Paris, France

    52 h-index

    620 publications

    78.8K citations

  5. Tokyo University of Science

    Tokyo, Japan

    49 h-index

    136 publications

    39.9K citations

  6. University of Pittsburgh

    Pittsburgh, United States

    48 h-index

    375 publications

    48.6K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    46 h-index

    76 publications

    42.6K citations

  8. Sun Yat-sen University

    Guangzhou, China

    45 h-index

    498 publications

    37.1K citations

1–8 of 3.8K

Venues

  1. The Journal of Immunology

    JI · 235 publications · 38.7K citations

    110

    h-index

  2. Immunity

    51 publications · 16.9K citations

    49

    h-index

  3. Journal of Allergy and Clinical Immunology

    66 publications · 9.2K citations

    49

    h-index

  4. The Journal of Experimental Medicine

    53 publications · 20.4K citations

    49

    h-index

  5. Nature Immunology

    51 publications · 30.8K citations

    48

    h-index

1–5