Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivaylo I. Ivanov, Koji Atarashi, Nicolas Manel, +14

Cell

DysbiosisMucosal ImmunologyMicrobiologyGut BarrierMicrobiome +3

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Ivaylo I. Ivanov, Rosa de Llanos, Nicolas Manel, +5

Cell Host & Microbe

DysbiosisIl-17-producing T-helper CellsMucosal ImmunologyHost-microbe InteractionsSmall Intestine +10

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

Marina Colombo, Catarina Moita, Guillaume van Niel, +7

Journal of Cell Science

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

Nicolas Manel, Derya Unutmaz, Dan R. Littman

Nature Immunology

Human Th-17 CellsSignal TransductionHuman GrowthImmune Cell DevelopmentLymphocyte Development +6

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

Matthew Raab, Matteo Gentili, Henry De Belly, +8

Science

The nucleus acts as a ruler tailoring cell responses to spatial constraints

Alexis J. Lomakin, Cédric J. Cattin, Damien Cuvelier, +17

Science

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

Nadia Jeremiah, Bénédicte Neven, Matteo Gentili, +15

Journal of Clinical Investigation

Innate Immune SystemImmunologyImmune RegulationPathologyImmunologic Mechanism +22

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

Jun R. Huh, Monica Leung, Pengxiang Huang, +14

Nature

InflammationRedox SignalingImmune Cell DevelopmentCell SignalingTh17 Cell Differentiation +7

The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV

Nicolas Manel, Felix J. Kim, Sandrina Kinet, +3

Cell

Signal TransductionG Protein-coupled ReceptorPhysiologyImmunologyDiabetes +2

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

Nicolas Manel, Brandon Hogstad, Yaming Wang, +3

Nature

Antiviral Innate ImmunityCryptic SensorCell SignalingHuman RetrovirusInnate Immune System +11