The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature · 2006 · 6.8K citations

Developmental Biology, Autoimmune Disease, Lymphocyte Development +13

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al. · Cell · 2006 · 5K citations · Full text

Inflammation, Cytokine, Lymphocyte Development +9

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Marc Veldhoen, Richard J. Hocking, Christopher J. Atkins et al. · Immunity · 2006 · 3.6K citations · Full text

Inflammation, Cytokine, Lymphocyte Development +9

Transforming growth factor-β induces development of the TH17 lineage

Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn et al. · Nature · 2006 · 3K citations

Developmental Biology, Th17 Lineage, Cell Proliferation +3

A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Richard H. Duerr, Kent D. Taylor, Steven R. Brant et al. · Science · 2006 · 3K citations · Full text

Inflammation, Chronic Inflammatory Diseases, Autoimmune Disease +13