Concepedia

T Cell Differentiation

T Cell Differentiation is a developmental and functional specialization process of T lymphocytes in adaptive immunity whereby hematopoietic precursors and naïve T cells undergo stage-specific changes in antigen receptor configuration, signaling, and gene-regulatory programs to generate distinct mature T-cell lineages and effector, memory, or regulatory subsets.

16.2K

Publications

1.6M

Citations

63.8K

Authors

5.9K

Institutions

Publications per year

2017–2026

2.3K

Parents

Children

Publications

16.2K

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science · 2003 · 8.1K citations

, , +17

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Jason D. Fontenot, Marc A. Gavin, Alexander Y. Rudensky · Nature Immunology · 2003 · 7.7K citations

, , +14

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature · 2006 · 6.9K citations

, , +16

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter et al. · Nature Immunology · 2010 · 5.8K citations · Full text

, , +17

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

Federica Sallusto, Danielle Lenig, Reinhold Förster et al. · Nature · 1999 · 5.8K citations

, , +14

1–5 of 16.2K

Authors

63.8K

  1. HV
    Harald von Boehmer

    Dana-Farber Cancer Institute, United States

    91 publications · 15.3K citations

    59

    h-index

  2. RA
    Richard A. Flavell

    Yale University, United States

    62 publications · 18.6K citations

    47

    h-index

  3. JC
    Juan Carlos Zúñiga‐Pflücker

    University of Toronto, Canada

    74 publications · 8.1K citations

    46

    h-index

  4. AY
    Alexander Y. Rudensky

    Howard Hughes Medical Institute, United States

    48 publications · 30K citations

    44

    h-index

  5. HR
    H. Robson MacDonald

    Ludwig Cancer Research, Switzerland

    76 publications · 8.5K citations

    43

    h-index

1–5 of 63.8K

Institutions

5.9K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    197 h-index

    1.7K publications

    415.6K citations

  2. Harvard University

    Cambridge, United States

    182 h-index

    2.9K publications

    604K citations

  3. National Institutes of Health

    Bethesda, United States

    177 h-index

    3.1K publications

    688.5K citations

  4. Inserm

    Paris, France

    134 h-index

    3.7K publications

    497.6K citations

  5. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    131 h-index

    1.3K publications

    271.5K citations

  6. Brigham and Women's Hospital

    Boston, United States

    124 h-index

    1.1K publications

    340.6K citations

  7. University of Pennsylvania

    Philadelphia, United States

    123 h-index

    1.6K publications

    327.8K citations

  8. National Cancer Institute

    Bethesda, United States

    114 h-index

    1.6K publications

    283.9K citations

1–8 of 5.9K

Venues

  1. Immunity

    466 publications · 141.1K citations

    211

    h-index

  2. The Journal of Immunology

    JI · 2.2K publications · 183.8K citations

    189

    h-index

  3. Nature Immunology

    341 publications · 125.2K citations

    184

    h-index

  4. Blood

    1.2K publications · 135.5K citations

    184

    h-index

  5. The Journal of Experimental Medicine

    768 publications · 124.4K citations

    180

    h-index

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