Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter, +11

Nature Immunology

Autoimmune DiseaseLymphocyte DevelopmentAdaptive Immune SystemImmunologyIntrathymic Cytokines +8

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

Xi Chen, Dimitrios Iliopoulos, Qing Zhang, +21

Nature

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

Wenxian Fu, Ayla Ergün, Ting Lu, +12

Nature Immunology

Transcriptional RegulationFunctional GenomicsGeneticsTranscriptional SignatureT-regulatory Cell +10

The transcription factor XBP1 is selectively required for eosinophil differentiation

Sarah E. Bettigole, Raphaël Lis, Stanley Adoro, +4

Nature Immunology

Transcriptional RegulationSignal TransductionGeneticsGene RegulationMolecular Genetics +6

Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC

François Van Laethem, Sophia D. Sarafova, Jung‐Hyun Park, +8

Immunity

ImmunologyImmunodominanceAntigen ProcessingAutoimmunityCd4 T Cell Responses +7

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR

Jung‐Hyun Park, Stanley Adoro, Philip J. Lucas, +9

Nature Immunology

InflammationCytokineSignal TransductionAdaptive Immune SystemImmune Cell Development +9

IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection

Stanley Adoro, Juan R. Cubillos‐Ruiz, Xi Chen, +14

Nature Communications

Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions

Longyong Xu, Xia Liu, Fanglue Peng, +24

Nature Cell Biology

Protein Quality ControlSystems BiologyCell RegulationEndoplasmic Reticulum-associated DegradationEndocytic Pathway +7

Post-translational control of T cell development by the ESCRT protein CHMP5

Stanley Adoro, Kwang Hwan Park, Sarah E. Bettigole, +7

Nature Immunology

T Cell DevelopmentDevelopmental BiologySignal TransductionCell RegulationLymphocyte Development +10

Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

Xia Liu, Jingjing Yu, Longyong Xu, +11

eLife