Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity

Wei Ying, Matthew Riopel, Gautam Bandyopadhyay, +9

Cell

ObesityMetabolic SyndromeSystems BiologyAdipose TissueDiabetes +9

Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes

Feyza Engin, Alena Yermalovich, Truc Nguyen, +5

Science Translational Medicine

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

Wenxian Fu, Ayla Ergün, Ting Lu, +12

Nature Immunology

Transcriptional RegulationFunctional GenomicsGeneticsTranscriptional SignatureT-regulatory Cell +10

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

Wei Ying, Yun Sok Lee, Yi Dong, +11

Cell Metabolism

ObesityMetabolic SyndromeInflammationInsulin SignalingIslet-resident Macrophages Leads +11

TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases

Bi-Huei Yang, Ke Wang, Shuo Wan, +10

Cell Reports

Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging

Wenxian Fu, Gregory R. Wojtkiewicz, Ralph Weissleder, +2

Nature Immunology

Complement SystemAutoimmune DiseasePhysiologyImmunologyDiabetes +7

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

Wenxian Fu, Júlia Farache, Susan M. Clardy, +8

eLife

Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075

Yudong Ji, Zhenlong Luo, Hong Gao, +9

Nature Metabolism

Extracellular MicrovesiclesInsulin SignalingObesityMetabolic SyndromeObese Mice +14

Synergetic effects of microbial-phytoremediation reshape microbial communities and improve degradation of petroleum contaminants

Ao Wang, Wenxian Fu, Feng Yu, +2

Journal of Hazardous Materials

EngineeringEnvironmental EngineeringBioremediationEnvironmental RemediationMicrobial Ecology +8

Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors

Alessandra Castiglioni, Yagai Yang, Katherine Williams, +28

Nature Communications