Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

Brian D. Lehmann, Joshua A. Bauer, Xi Chen, +4

Journal of Clinical Investigation

Androgen ReceptorBreast OncologyTumor BiologyOncologyTumor Heterogeneity +14

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

Xi Chen, Xu Han, Ping Yuan, +20

Cell

Transcriptional RegulationSystems BiologyDevelopmental BiologyCell LineageCore Transcriptional Network +12

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

Yuin‐Han Loh, Qiang Wu, Joon-Lin Chew, +19

Nature Genetics

Nanog Transcription NetworkInduced Pluripotent Stem CellDevelopmental BiologyMedicineStem Cell Research +5

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

Jin Ye, Robert B. Rawson, Ryutaro Komuro, +5

Molecular Cell

Protein SecretionProtein FunctionSignal TransductionBiochemistryMedicine +11

ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

Jingshi Shen, Xi Chen, Linda M. Hendershot, +1

Developmental Cell

Protein FunctionSignal TransductionGolgi Localization SignalsNatural SciencesMolecular Regulation +10

Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection

Brian D. Lehmann, Bojana Jovanović, Xi Chen, +6

PLoS ONE

Breast OncologyPathologyNeoadjuvant Chemotherapy SelectionTumor BiologyOncology +14

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Joyce W. Lustbader, Maurizio Cirilli, Chang Lin, +18

Science

Mitochondrial DysfunctionMolecular BiologyCell DeathNeurochemical BiomarkersSocial Sciences +16

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

Fabio Martinon, Xi Chen, Ann–Hwee Lee, +1

Nature Immunology

InflammationToll-like ReceptorsMolecular ImmunologyCytokineAutoimmune Disease +12

Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non–Small-Cell Lung Cancer

Zhibin Hu, Xi Chen, Yang Zhao, +8

Journal of Clinical Oncology

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

Xi Chen, Dimitrios Iliopoulos, Qing Zhang, +21

Nature