Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter, +11

Nature Immunology

Autoimmune DiseaseLymphocyte DevelopmentAdaptive Immune SystemImmunologyIntrathymic Cytokines +8

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Shimon Sakaguchi, N Sakaguchi, M Asano, +2

The Journal of Immunology

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Craig L. Bennett, Jacinda R. Christie, Fred Ramsdell, +7

Nature Genetics

Autoimmune DiseaseDisease MechanismGenetic DisorderGeneticsPathogenesis +10

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Mary E. Brunkow, Eric W. Jeffery, Kathryn A. Hjerrild, +7

Nature Genetics

New Forkhead/winged-helix ProteinImmunologyPathologyFatal Lymphoproliferative DisorderMorphogenesis +4

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

Robert S. Wildin, Fred Ramsdell, Jane Peake, +13

Nature Genetics

Knockout MouseMetabolic SyndromeHuman EquivalentXenotransplantationGrowth Hormone +8

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

Martha S. Jordan, Alina C. Boesteanu, Amy J. Reed, +5

Nature Immunology

Signal TransductionAutoimmune DiseaseLymphocyte DevelopmentT-regulatory CellImmunology +9

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

Chrystelle Asseman, Smita Mauze, Michael W. Leach, +2

The Journal of Experimental Medicine

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 <i>scid</i> mice

Fiona Powrie, Michael W. Leach, Smita Mauze, +2

International Immunology

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

Talal A. Chatila, Frank Blaeser, Nga Ho, +4

Journal of Clinical Investigation

ImmunodeficienciesImmunologyImmune RegulationImmunodominanceTh Cell Differentiation +15

Origin of regulatory T cells with known specificity for antigen

Irina Apostolou, Adélaïda Sarukhan, Ludger Klein, +1

Nature Immunology

Autoimmune DiseaseAllergyT-regulatory CellImmunologyRegulatory T Cells +8