ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

TLDR

The nuclear envelope separates genomic DNA from the cytoplasm and regulates protein trafficking, and its integrity during interphase is essential. The nuclear envelope reseals rapidly during interphase, assisted by components of the ESCRT III membrane‑remodeling machinery. Migrating immune and cancer cells experience frequent, transient nuclear envelope ruptures when moving through tight spaces. See Raab et al.

Abstract

Repairing tears in the nuclear envelope The nuclear envelope segregates genomic DNA from the cytoplasm and regulates protein trafficking between the cytosol and the nucleus. Maintaining nuclear envelope integrity during interphase is considered crucial. However, Raab et al. and Denais et al. show that migrating immune and cancer cells experience frequent and transitory nuclear envelope ruptures when they move through tight spaces (see the Perspective by Burke). The nuclear envelope reseals rapidly during interphase, assisted by components of the ESCRT III membrane-remodeling machinery. Science , this issue pp. 359 and 353 ; see also p. 295