Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Laurie E. Harrington, Robin D. Hatton, Paul R. Mangan, +4

Nature Immunology

Lymphocyte DevelopmentImmune Cell DevelopmentAdaptive Immune SystemImmunologyT Cell Immunity +8

Transforming growth factor-β induces development of the TH17 lineage

Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn, +7

Nature

Developmental BiologyTh17 LineageCell ProliferationCell GrowthGene Expression +1

The AP-1 transcription factor Batf controls TH17 differentiation

Barbara U. Schraml, Kai Hildner, Wataru Ise, +13

Nature

Transcriptional RegulationGeneticsGene RegulationGene ExpressionMedicine +4

Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria

Rajatava Basu, Darrell B. O’Quinn, Daniel J. Silberger, +5

Immunity

Host ResponseMucosal ImmunologyTh22 Cells ArePathogenesisImmunology +10

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

Ryuta Mukasa, Anand Balasubramani, Yun Kyung Lee, +6

Immunity

ChromatinLineage PlasticityCell LineageLymphocyte DevelopmentGenetics +7

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

Daniel DiToro, Colleen J. Winstead, Duy Pham, +16

Science

Regulatory T Cell Suppression and Anergy Are Differentially Regulated by Proinflammatory Cytokines Produced by TLR-Activated Dendritic Cells

Takekazu Kubo, Robin D. Hatton, James R. Oliver, +3

The Journal of Immunology

Tlr ActivationT-regulatory CellImmunologyRegulatory T CellsImmunotherapy +16

A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK Cells

Robin D. Hatton, Laurie E. Harrington, Rita J. Luther, +6

Immunity

MedicineImmunologyImmunologic MechanismAutoimmunityT Cell Immunity +6

Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity

Daniel DiToro, Stacey N. Harbour, Jennifer K. Bando, +15

Immunity

Autoimmune DiseaseInsulin-like Growth FactorsT-regulatory CellImmunologyT Helper 17 +9

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell–iTreg cell balance

Rajatava Basu, Sarah K. Whitley, Suniti Bhaumik, +6

Nature Immunology

InflammationCytokineTranscriptional RegulationCell RegulationImmune Cell Development +10