Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

Maj-Linda B. Selenica, Milene L. Brownlow, Jeffy P. Jimenez et al. · Neurodegenerative Diseases · 2012 · 10.4K citations · Full text

Life Sciences, Neurology, Neuroscience +17

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Holly D. Oakley, Sarah L. Cole, Sreemathi Logan et al. · Journal of Neuroscience · 2006 · 3.6K citations · Full text

Life Sciences, Neurology, Neuroscience +17

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Daniel Martinez Molina, Rozbeh Jafari, Marina Ignatushchenko et al. · Science · 2013 · 2.2K citations

Medicine, Oncology, Pharmacology +17

High throughput artificial membrane permeability assay for blood–brain barrier

Li Di, Edward H. Kerns, Kristi Fan et al. · European Journal of Medicinal Chemistry · 2003 · 1.1K citations

Pharmacy, Biomedical Engineering, Neuroscience +11

The promise and peril of chemical probes

C.H. Arrowsmith, James E. Audia, Christopher P. Austin et al. · Nature Chemical Biology · 2015 · 850 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +12