Holly D. Oakley

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Holly D. Oakley, Sarah L. Cole, Sreemathi Logan et al. · Journal of Neuroscience · 2006 · 3.4K citations · Full text

BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

Masuo Ohno, Evgeny A. Sametsky, Linda H. Younkin et al. · Neuron · 2004 · 560 citations · Full text

Alzheimer's Disease, Dementia, Frontotemporal Dementia +8

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1

Masuo Ohno, Lei Chang, Wilbur Tseng et al. · European Journal of Neuroscience · 2006 · 301 citations

Brain Function, Soluble Abeta Oligomers, Temporal Memory Deficits +18

Lysosomal signaling molecules regulate longevity in <i>Caenorhabditis elegans</i>

Andrew Folick, Holly D. Oakley, Yong Yu et al. · Science · 2015 · 281 citations

Lifespan Extension, Crucial Cellular Organelles, Signaling Role +15

Statins Cause Intracellular Accumulation of Amyloid Precursor Protein, β-Secretase-cleaved Fragments, and Amyloid β-Peptide via an Isoprenoid-dependent Mechanism

Sarah L. Cole, Aneta Grudzien, Ingrid O. Manhart et al. · Journal of Biological Chemistry · 2005 · 135 citations · Full text

Amyloid β-Peptide, Isoprenoid-dependent Mechanism, Protein Secretion +15