C.H. Arrowsmith

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

P. Filippakopoulos, S. Picaud, Maria Mangos et al. · Cell · 2012 · 1.7K citations · Full text

Structural Bioinformatics, Epigenetic Change, Genetics +25

Consistent blind protein structure generation from NMR chemical shift data

Yang Shen, Oliver F. Lange, Frank Delaglio et al. · Proceedings of the National Academy of Sciences · 2008 · 853 citations · Full text

Biochemistry, Biomolecular Structure Prediction, Protein Folding +12

The promise and peril of chemical probes

C.H. Arrowsmith, James E. Audia, Christopher P. Austin et al. · Nature Chemical Biology · 2015 · 836 citations · Full text

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

Ling Huang, Audrey Holtzinger, Ishaan Jagan et al. · Nature Medicine · 2015 · 737 citations · Full text

Induced Pluripotent Stem Cell, Patient-derived Tumor Organoids, Engineering +12

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

Damian Yap, Justin Chu, Tobias Berg et al. · Blood · 2010 · 592 citations · Full text