James E. Audia

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

Harry F. Dovey, Varghese John, J. P. Anderson et al. · Journal of Neurochemistry · 2001 · 879 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

The promise and peril of chemical probes

C.H. Arrowsmith, James E. Audia, Christopher P. Austin et al. · Nature Chemical Biology · 2015 · 850 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +12

In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life.

John R. Cirrito, Patrick C. May, Mark Odell et al. · PubMed · 2003 · 426 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

<i>In Vivo</i>Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

John R. Cirrito, Patrick C. May, Mark Odell et al. · Journal of Neuroscience · 2003 · 412 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor

Patrick C. May, Robert A. Dean, Stephen L. Lowe et al. · Journal of Neuroscience · 2011 · 369 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16